Immune Cell Phenotype and Function in Sepsis
نویسندگان
چکیده
منابع مشابه
Targeting Immune Cell Checkpoints during Sepsis
Immunosuppression is increasingly being recognized as one of the causes of increased morbidity and mortality during sepsis. Both innate and adaptive immune system dysfunction have been shown to cause an impaired ability to eradicate the primary infection and also lead to frequent occurrence of secondary opportunistic infections. Pre-clinical and clinical studies have shown that inhibitory immun...
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Sepsis is a life threatening condition mediated by systemic infection, but also triggered by hemorrhage and trauma. These are significant causes of organ injury implicated in morbidity and mortality, as well as post-sepsis complications associated with dysfunction of innate and adaptive immunity. The role of cellular bioenergetics and loss of metabolic plasticity of immune cells is increasingly...
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Description of Procedure or Service Populations Interventions Comparators Outcomes Individuals: With a solid organ transplant Interventions of interest are: Immune cell function assay Comparators of interest are: Standard monitoring of immunosuppression Relevant outcomes include: Overall survival Test accuracy Other test performance measures Morbid events Individuals: With a hem...
متن کاملSepsis and immune response.
BACKGROUND Sepsis and secondary multiple organ failure in critically ill patients are the major cause of death, but the pathogenesis of sepsis is not clear, especially the dysfunction of the immune system. In this paper, we review the response and regulation of the immune system and the functions of a variety of inflammatory mediators in sepsis. DATA SOURCES Studies were identified by searchi...
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MicroRNA (miRNA) are small, non-coding RNA molecules that have been linked with immunity through regulating/modulating gene expression. A role for these molecules in T-cell and B-cell development and function has been well established. An increasing body of literature now highlights the importance of specific miRNA in dendritic cell (DC) development as well as their maturation process, antigen ...
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ژورنال
عنوان ژورنال: Shock
سال: 2016
ISSN: 1073-2322
DOI: 10.1097/shk.0000000000000495